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It is well known that CD88 on neutrophils interacts with C5a to produce a series of functional responses such as chemotaxis, enzyme release, degranulation, and respiratory burst.

. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets.

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2), favors chemotaxis of stimulated neutrophils.

, 1978). . The presence of Staphylococcus aureus in the blood results in the rapid activation of an immune response, primarily an innate immune response.

Nov 24, 2021 · Neutrophil Chemotaxis Towards C5a and C3a Through Small Channels.

. . The cells are allowed to migrate for 2 h at 37°C and.

. ; Callaway,.

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This report describes experiments examining the role of surface-bound C5a on.

The presence of Staphylococcus aureus in the blood results in the rapid activation of an immune response, primarily an innate immune response. Mar 1, 2004 · Chemotaxis of human neutrophils toward chemoattractants C5a and fMLP was determined using BCECF-labeled neutrophils as previously described.

e In vitro neutrophil chemotaxis assays with recombinant versions of platelet-secreted. Immunol.

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chemotaxis induced by CXCL2 and C5a.

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; Callaway,.

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R. . . As complement activation by GXM was minimal at the doses applied in vivo, it is unlikely that generation of chemotactic C5a in the circulation by GXM caused the observed reduction in leucocyte migration. .

A neutrophil chemoluminescence assay was normal, and a neutrophil chemotaxis study revealed normal random migration, normal directed migration to E coli chemoattractant, and significantly diminished migration to C5a, which was verified in 2 different assays.

. CD44 and Annexin A2 mediate the C5a chemotactic cofactor function of the vitamin D binding protein.

The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets.

CD44 and Annexin A2 mediate the C5a chemotactic cofactor function of the vitamin D binding protein.

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For neutrophil migration to the inflamed region, we hypothesized that the complement activation product C5a induces significant changes in cellular morphology before.